1,25-D, the active form of vitamin D, activates the Vitamin D Nuclear Receptor, impacting immune function genes. Elevated levels in chronic inflammatory conditions can disrupt other receptors and be hindered by pathogen-generated substances. Discussions on vitamin D deficiency typically focus on 25-D levels rather than 1,25-D. Testing 1,25-D proves valuable in specific contexts, like assessing inflammation and therapy effectiveness. Its levels can fluctuate naturally, notably in women during their menstrual cycle. Interpreting results requires context and adherence to specific testing guidelines. While lab ranges might skew high, reliable studies suggest lower average levels in healthy individuals, differing from typical references.
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