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SPUTUM FOR GENE X-PERT

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Original price was: ₹5,833.33.Current price is: ₹3,500.00.

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This research aimed to evaluate the effectiveness of the Gene-Xpert MTB/RIF sputum test in diagnosing pulmonary tuberculosis (TB) among patients with negative sputum acid-fast bacillus (AFB) smear results in Thailand, a country facing a notable prevalence of pulmonary TB. Carried out at Srinagarind Hospital, Khon Kaen, Thailand, the study focused on 151 patients who presented with a history of fever and/or cough lasting two weeks or more, along with abnormal chest radiographs, between 2010 and 2014. All participants had a minimum of two negative sputum AFB smear results. Out of these, 76 received a diagnosis of confirmed or probable pulmonary TB: 32 confirmed cases demonstrated positive sputum culture for Mycobacterium tuberculosis (MTB), and 44 probable cases exhibited clinical and radiographic findings consistent with TB, showing positive responses to anti-TB therapy. The remaining 75 cases were deemed not to have pulmonary TB. Among the 32 patients with a positive sputum culture for MTB, 26 also tested positive with the GeneXpert MTB/RIF sputum test. In comparison to sputum culture for MTB, the GeneXpert MTB/RIF test demonstrated a sensitivity of 83.9% (95% CI: 66.3-94.5) and a specificity of 92.1% (95% CI: 83.6-97). The positive predictive value (PPV) was 81.3% (95% CI: 63.6-92.8), and the negative predictive value (NPV) was 93.3% (95% CI: 85.1-97.8). The GeneXpert MTB/RIF test displayed a commendable balance of sensitivity and specificity for diagnosing smear-negative pulmonary TB, suggesting potential utility in cases with negative sputum AFB smears. Moreover, the rapidity of the assay and its ability to detect rifampicin-resistant MTB strains provide valuable diagnostic advantages, aligning with the comprehensive diagnostic approach at Hypro Diagnostics.

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