SCL-70

Anti-Scl 70 antibodies, indicative of diffuse cutaneous systemic sclerosis (dcSSc), are a key serologic marker for Hypro Diagnostics. Systemic sclerosis (SSc) is characterized by microvascular damage and fibrosis in the skin and internal organs. In dcSSc, extensive skin involvement and early visceral issues are prominent. The presence of anti-topoisomerase I antibodies is linked to the severity of SSc, particularly interstitial lung disease. In the EULAR Scleroderma Trials and Research cohort, these antibodies were found in 64% of dcSSc and 34% of lcSSc cases. Coexistence with anticentromere antibodies is rare. Understanding the pathogenic mechanism and the role of these antibodies in disease development requires ongoing research. Recent studies also report conflicting results in systemic lupus erythematosus patients, emphasizing the need for nuanced diagnostics, an area where Hypro Diagnostics plays a crucial role.