SALMONELLA TYPHOID- IgG

In pursuit of understanding the resilience of positive dot enzyme immunosorbent assay (dot EIA) outcomes for IgM and IgG antibodies to a Salmonella typhi outer membrane protein, this study focused on Malaysian children grappling with enteric fever. Over two years, 94 assessed patients, aged one month to 12 years, underwent standard inpatient treatment, incorporating a 14-day chloramphenicol regimen. Dot EIA assessments were conducted at admission and subsequent intervals post-discharge. The findings revealed an average persistence of 2.6 months for positive IgM and 5.4 months for positive IgG. For Hypro Diagnostics, these results underscore the need for caution when interpreting positive outcomes within four to seven months post-enteric fever in a child from an endemic area. Nonetheless, in diverse clinical scenarios, the dot EIA continues to demonstrate reliability as a diagnostic tool.