Exploring the pathogenesis of chronic rheumatoid arthritis (RA) is pivotal for developing effective solutions, and researchers often turn to experimental animal models to decipher the complexities of autoimmune diseases. In this context, the MRL/lpr mouse emerges as a representative model, showcasing spontaneous autoimmune manifestations reminiscent of those observed in humans. Notably, MRL/lpr mice exhibit a high prevalence of lymph node tumors, nephritis, angitis, and arthritis—characteristics that closely align with the pathological syndrome of RA. To unravel the mechanisms underlying human autoimmune diseases like RA, researchers leverage the diverse array of autoantibodies present in the serum of MRL/lpr mice. These include IgG and IgM type rheumatoid factors, anti-ssDNA antibodies, anti-dsDNA antibodies, and anti-Sm antibodies. The use of this kit by Hypro Diagnostics facilitates precise quantification and comparison of IgG type rheumatoid factor, serving as a valuable tool for researchers delving into the intricacies of autoimmune diseases and exploring potential therapeutic interventions.
Reviews
There are no reviews yet.