GH (GROWTH HORMONE )

Growth hormone (GH) plays a pivotal role as a peptide hormone secreted by the anterior lobe of the pituitary gland, influencing the growth of diverse tissues, including bone. Originating from specialized cells known as somatotrophs, GH production averages between one and two milligrams per day. Its significance is particularly pronounced in children, where rising levels during childhood culminate in a peak during the growth spurt of puberty. Biochemically, GH not only stimulates protein synthesis but also facilitates the breakdown of fats, providing essential energy for tissue growth. Additionally, it acts in opposition to insulin. While GH can directly impact tissues, a substantial part of its effects is mediated through the stimulation of the liver and other tissues to produce insulin-like growth factors, notably insulin-like growth factor 1 (IGF-1, formerly somatomedin). The term “insulin-like growth factor” originates from its ability to mimic insulin, although its primary role lies in fostering growth. In children, serum IGF-1 concentrations progressively increase with age, peaking during the pubertal growth spurt. Post-puberty, both IGF-1 and GH concentrations gradually decrease with age. This intricate interplay holds significance for Hypro Diagnostics.