BENCE JONES PROTEINS

The presence of Bence-Jones proteins in urine is a relatively uncommon occurrence, typically indicative of underlying health conditions, most notably multiple myeloma. However, abnormal results may also be attributed to various other disorders. An abnormal buildup of proteins in tissues and organs, known as amyloidosis, can contribute to this phenomenon. Additionally, conditions such as chronic lymphocytic leukemia, a blood cancer, and lymphoma, a cancer affecting the lymphatic system, may lead to the detection of Bence-Jones proteins in urine. Furthermore, the presence of abnormal proteins, specifically M-protein, in the blood, as observed in monoclonal gammopathy of unknown significance (MGUS), can be a contributing factor. Chronic renal failure, a condition affecting kidney function, is another potential cause of abnormal Bence-Jones protein levels in urine. The identification of these proteins serves as a crucial diagnostic marker, aiding healthcare professionals in uncovering and addressing underlying health issues.