ANTI L.K.M ANTIBODY

Anti-LKM antibodies, detected via immunofluorescence on tissues, distinguish themselves from anti-mitochondrial antibodies. These antibodies comprise three types—LKM-1, LKM-2, and LKM-3—each exhibiting distinct staining patterns. LKM-1 targets proximal renal tubules and hepatocytes, while LKM-2 shows a unique pattern in mouse liver and renal tubules. LKM-3 requires human pancreas for detection, displaying a particular exocrine staining. These antibodies are specific markers in certain liver conditions and offer insights into disease progression, aiding accurate diagnosis and treatment planning, particularly in autoimmune chronic active hepatitis.